The expressway, spanning over 110 km, connects Can Tho city with Hau Giang, Bac Lieu, Kien Giang, and Ca Mau provinces, complemented by 25.85 km of connecting routes.

Prime Minister Pham Minh Chinh on December 15 inspected the construction of the Can Tho–Ca Mau Expressway, during which he encouraged workers at the site and directed measures to speed up the project's progress.