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Vietnamese scientist discovers anti-cancer agents from rice husks

Vietnamese scientist Prof. Dr. Tran Dang Xuan and his colleagues at Hiroshima University in Japan have discovered anti-cancer agents in rice husks.
Vietnamese scientist discovers anti-cancer agents from rice husks ảnh 1Illustrative image (Photo: thethaovanhoa.vn)
 

Tokyo (VNA) – Vietnamese scientist Prof.Dr. Tran Dang Xuan and his colleagues at Hiroshima University in Japan havediscovered anti-cancer agents in rice husks.

The research titled ‘Cytotoxic Mechanism ofMomilactones A and B against Acute Promyelocytic Leukemia and Multiple MyelomaCell Lines’ was published on Cancers magazine in October thisyear.

This is the first study clarifying thecytotoxic mechanism of Momilactones A (MA) and Momilactones B (MB) on acute promyelocyticleukemia (APL) HL-60 and multiple myeloma (MM) U266 cell lines.

Besides, these compounds may induce G2 phasearrest in the HL-60 cell cycle through the activation of p-38 and disruption ofCDK1 and cyclin B1 complex.

This finding provides novel insights into the anticancer property of Momilactones, which can be a premise for future studies and development of Momilactone-based anti-cancer medicines.

The Laboratory of Plant Physiology and Biochemistry in Hiroshimas University led by Xuan is one of the few laboratories in the world that can purify Momilactones from natural sources such as rice. In a study in 2019, the group discoveredand successfully extracted 600 mg of MA and MB from 30kg of rice husks.

﷽ The scientist said many pharmaceutical companies inside and outside Japan are workingwith his team to extract MA and MB for developing medicines to boost the immunesystem, anti-cancer medicines, those for treating diabetes, and cosmetics./. 

VNA

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